TEC-funded MPhil/PhD Student Abstract
| Title | : | Biological and Catalytic Evaluations of Derivatives of Diaryl Sulfides / Disulfides and their Metal Complexes |
| Student | : | MOOSUN- HOSSENBUX Salma |
| Institution | : | Faculty of Science, University of Mauritius |
| Level | : | MPhil - FT Year : 2010 |
| Supervisor | : | Assoc Prof S. Jhaumeer Laulloo, Assoc Prof M. G. Bhowon |
| Abstract | : | Aryl sulfides and their diversified applications have been a fascinating area of research for the last past decades. This increasing interest has led to the design of efficient and high yield methods for their common synthesis. Despite significant improvements, there are still limitations in the synthesis and application of aryl sulfides compounds due to poor solubility and consequently there is interest in further development. To overcome these problems, derivatives of diaryl sulfides with different substituents will be explored.
Carbon-sulphur bonds are prevalent in numerous pharmaceutical and biologically active compounds. Complexes involving ligands in which sulphur is the donor atom are also of interest due to the nature of the metal-sulfur bonding interaction. Aryl sulfide ligands and ruthenium complexes of derivatives of bis phenyl disulfide will be screened for their different biological properties including antimicrobial, antioxidant and DNA-binding.
Moreover these sulfide derivatives are known to be excellent stereochemical control as chiral auxiliaries in C-C bond forming reactions. The C-C bond forming reactions (Michael, Heck or Suzuki) require harsh conditions and other organometallic catalysts, which speed up given reactions by lowering the energy barrier without being consumed, need to be synthesised to improve yields, selectivity and ease of work. The efficiency of the catalysts (synthesised metal complexes of aryl sulphides/disulfides) in C-C bond formation will be studied.
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